Dimethyl Sulfoxide
Apexbio Technology LLC Ciprofibrate 52214-84-3 10mM (in 1mL DMSO)
Ciprofibrate is a selective agonist targeting peroxisome proliferator-activated receptor alpha (PPAR ) a nuclear receptor involved in regulating lipid metabolism and energy homeostasis Its activation promotes gene expression linked to fatty acid oxidation triglyceride reduction and cholesterol metabolism Ciprofibrate is frequently applied as a molecular tool in biomedical research to investigate mechanisms underlying dyslipidemia atherosclerosis and metabolic-related disorders Additionally due to its receptor-specific mode of action it serves as a standard experimental reference in in vitro assays and animal models assessing lipid-lowering therapeutic strategies and PPAR -dependent signaling pathways
Apexbio Technology LLC KU 55933 587871-26-9 10mM (in 1mL DMSO)
KU 55933 (CAS 587871-26-9) is a selective inhibitor of ATM kinase with an IC50 of 13 nM ATM kinase promotes insulin-induced Akt activation via phosphorylation of Akt at Ser473 KU 55933 inhibition of ATM significantly reduces Akt Ser473 phosphorylation in insulin- or IGF-I-treated MDA-MB-453 and PC-3 cells resulting in suppressed proliferation cell cycle arrest at G1 phase and decreased cyclin D1 levels KU 55933 serves as a tool for studying ATM-related signaling and Akt-driven cancer cell growth regulation
Apexbio Technology LLC Calcitriol 32222-06-3 10mM (in 1mL DMSO)
Calcitriol the biologically active metabolite of vitamin D3 functions primarily through interaction with the intracellular vitamin D receptor (VDR) regulating transcription of genes involved in mineral homeostasis and immune responses It modulates cellular differentiation proliferation and adaptive immune functions via nuclear receptor-mediated mechanisms In vitro studies demonstrate that calcitriol dose-dependently inhibits lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF- ) and interleukin-1 (IL-1 ) secretion from human peripheral blood mononuclear cells (PBMCs) Additionally animal models indicate that calcitriol administration decreases cytokine release associated with inflammatory stimuli through intracellular calcium-dependent signaling pathways Calcitriol is widely utilized in biomedical research concerning osteometabolic regulation immune modulation and cytokine signaling networks
Apexbio Technology LLC Laquinimod (ABR-215062) 248281-84-7 10mM (in 1mL DMSO)
Laquinimod (ABR-215062 CAS 248281-84-7) is an orally bioavailable immunomodulatory small molecule Research studies demonstrate that in experimental autoimmune encephalomyelitis (EAE) a widely utilized rodent model for studying human multiple sclerosis (MS) laquinimod treatment suppresses disease progression in a dose-dependent manner Mechanistically the compound reduces inflammatory infiltration of CD4 T lymphocytes and macrophages into the central nervous system thereby modulating the Th1/Th2 immune response and inducing regulatory cytokines such as TGF- Clinical investigations into relapsing MS indicate that laquinimod administration correlates with reduced disease activity clinical relapse rate MRI-measured lesions and brain volume loss
Apexbio Technology LLC BML-277 516480-79-8 10mM (in 1mL DMSO)
BML-277 (CAS 516480-79-8) is a potent ATP-competitive inhibitor of checkpoint kinase 2 (Chk2) with an IC50 of approximately 15 nM and a Ki value of 37 nM Mechanistically BML-277 binds specifically to the ATP-binding site of Chk2 blocking its kinase activity In cellular assays BML-277 demonstrates concentration-dependent protective effects against irradiation-induced apoptosis in T-cells with EC50 values ranging from 3 to 7 6 M Due to its selective Chk2 inhibition BML-277 serves as a valuable reagent in studying DNA damage checkpoint pathways and their roles in cell survival and apoptosis
Apexbio Technology LLC Pioglitazone HCl 112529-15-4 10mM (in 1mL DMSO)
Pioglitazone HCl is a potent and highly selective agonist of the peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor involved in glucose and lipid metabolism regulation Acting via PPAR activation pioglitazone increases insulin sensitivity in hepatic adipose and peripheral tissues enhancing insulin-mediated glucose uptake and utilization Pioglitazone requires the presence of insulin to exert its biological activity through receptor activation limiting its application in scenarios characterized by substantial insulin deficiency Clinically pioglitazone HCl has been widely applied in the management and investigation of hyperglycemia associated with type 2 diabetes mellitus (T2DM) Additionally pioglitazone demonstrates effects on lipid regulation notably reducing triglyceride levels and increasing high-density lipoprotein (HDL) cholesterol making it useful in metabolic research
Apexbio Technology LLC IOX2(Glycine) 931398-72-0 10mM (in 1mL DMSO)
IOX2(Glycine) (CAS 931398-72-0) is a selective inhibitor targeting hypoxia-inducible factor-prolyl hydroxylase-2 (PHD2) a key enzyme regulating oxygen sensing by mediating hydroxylation of HIF-1 IOX2 exhibits high target specificity demonstrating an IC50 of approximately 21 nM against PHD2 in vitro and negligible inhibition (over 100-fold selectivity) toward related enzymes such as JMJD2 isoforms and the 2OG-oxygenase FIH In RCC4 cells IOX2 at 50 M effectively suppresses HIF-1 hydroxylation highlighting its utility as a pharmacological probe in studying hypoxia signaling pathways and oxygen-dependent cellular responses
Apexbio Technology LLC Aloperine 56293-29-9 10mM (in 1mL DMSO)
Aloperine is a naturally derived alkaloid known for its biological properties including anti-inflammatory antiviral antibacterial and antitumor activities Mechanistic studies suggest that aloperine exerts anti-inflammatory effects through inhibition of inflammatory mediators and inflammatory signaling pathways such as nuclear factor-kappa B (NF- B) and mitogen-activated protein kinase (MAPK) pathways In vitro assays demonstrate antiviral potential related to inhibition of specific viral replication stages Additionally its antitumor properties have been identified in multiple cancer cell lines where aloperine can induce apoptosis inhibit proliferation and migration and modulate cell cycle progression Aloperine typically exhibits IC50 values ranging from low micromolar to sub-micromolar concentrations depending on cell lines and experimental settings It serves as a research tool compound in immunological oncological and infectious disease studies
Apexbio Technology LLC RO5126766(CH5126766) 946128-88-7 10mM (in 1mL DMSO)
RO5126766 (CH5126766 CAS 946128-88-7) is a dual Raf/MEK inhibitor that targets the RAS/RAF/MEK/ERK signaling pathway involved in cellular proliferation survival and differentiation By inhibiting RAF-dependent MEK1 phosphorylation and subsequent MEK-mediated ERK activation RO5126766 suppresses downstream signaling In vitro kinase assays show IC50 values of 0 0082 0 056 M for MEK1 phosphorylation and 0 16 M for MEK1-induced ERK2 activation Studies in KRAS-mutant cancer cell lines such as HCT116 and NCI-H460 demonstrate that RO5126766 blocks MEK and ERK phosphorylation effectively inducing cell cycle arrest at the G1 stage Thus RO5126766 serves as a valuable research tool for investigating tumor biology driven by MAPK signaling dysregulation
Supply Solutions Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
FUJIFILM BIOSCIENCES INC CultureSure DMSO
This product is DMSO dimethyl sulfoxide for cell culture It can be used to dissolve compounds added to culture media and to prepare cryopreservation solutions
Apexbio Technology LLC CP-724714 537705-08-1 10mM (in 1mL DMSO)
CP-724714 (CAS 537705-08-1) is a small molecule inhibitor selectively targeting erbB2 (Her2) and EGFR kinases with notable potency against erbB2 kinase (IC50 10 3 nM) and considerably lower activity toward EGFR kinase (IC50 6 400 2 100 nM) In cellular assays CP-724714 induces G1 cell-cycle arrest and decreases erbB2 phosphorylation in Her2-overexpressing BT-474 breast cancer cells In animal xenograft models (BT-474 MDA-MB-453) it reduces erbB2 receptor phosphorylation and downstream signaling resulting in tumor growth inhibition and apoptosis induction CP-724714 advanced into phase I clinical trials for Her2-driven breast cancer research
Medchemexpress LLC Dbet6 10Mm 1Md Dmso Reconstit | HY-112588-10MM-DMSO-RECON
Dbet6 10Mm 1Md Dmso Reconstit